Wells LabUCSF, Depts of Pharmaceutical Chemistry and Cellular and Molecular Pharmacology


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Degrabase 1.0
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The status of the α-aminome, or all protein N-termini at a given time in a cell, can provide a wealth of information regarding protein turnover, protein trafficking, and protease signaling. The Degrabase aim to provide a non-biased description of all possible caspases substrates found in healthy and apoptotic human cells. This page was created to share with the scientific community this valuable dataset that contains over 8,000 unique α-amines detected with high confidence using mass spectrometry and our degradomics methodology.


Apoptotic cells Untreated cells Both
All amino acids "D" only

Enter a protein substrate:

e.g. Caspase, CASP3, or P42574
(uniprot name (CASP3_HUMAN) and accession number (P42574) are more accurate)

Find the official entry name of your protein of interest: http://uniprot.org


Crawford E.D.,* Seaman J.E.,* Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H., Zhuang M., Chalkley R.J., Wells J.A. (2013) "The DegraBase: a database of proteolysis in healthy and apoptotic human cells." Mol. Cell. Proteomics 12. 813-824.